What is Sildenafil?

Sildenafil is a medication primarily used to treat erectile dysfunction (ED) in men. It belongs to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors.

Originally, Sildenafil was developed as a treatment for hypertension (high blood pressure) and angina (chest pain). However, clinical trials showed, that sildenafil has a significant effect on enhancing penile erections. As a result, creator repurposed it for use in treating ED under brand name Viagra.

In addition to its use for erectile dysfunction, doctors also prescribe sildenafil to treat pulmonary arterial hypertension (PAH). A condition characterized by high blood pressure in the arteries that supply the lungs.

How does Viagra work?

Sildenafil, a. k. a. Viagra, works by inhibiting an enzyme called phosphodiesterase type 5 (PDE5). This enzyme is responsible for breaking down a chemical called cyclic guanosine monophosphate (cGMP) in the smooth muscle cell lining the blood vessels to the penis.

During sexual arousal, the release of nitric oxide in the penis leads to the production of cGMP, which causes the smooth muscles in the penile blood vessels to relax. This relaxation allows blood to flow into the penis, resulting in an erection.

PDE5 normally breaks down cGMP, limiting its effects and causing the smooth muscles to contract, reducing blood flow and causing the loss of the erection. By inhibiting PDE5, sildenafil prevents the breakdown of cGMP, allowing it to accumulate and prolonging its effects. This, in turn, helps to maintain the relaxation of the smooth muscles, promoting increased blood flow to the penis and facilitating an erection.

It is important to note that sildenafil does not directly cause an erection. Sexual stimulation is still necessary to initiate the release of nitric oxide and the production of cGMP. Sildenafil simply enhances the natural physiological processes involved in achieving and maintaining an erection. This makes it easier for men with erectile dysfunction to respond to sexual stimulation.

How to use Viagra?

Viagra is available in tablet form. The recommended dose is typically 50mg, although it can vary depending on individual needs and tolerability. It is important to take Viagra approximately one hour before sexual activity, as it takes time for the medication to become effective. You can take it with or without food, but a high-fat meal may delay its onset of action.

It is crucial to follow the instructions provided by your doctor or the medication label. Do not exceed the recommended dose, and do not take more than one tablet in a 24-hour period. You should not take viagra more than once a day.

Warnings and Contradictions

Prior to using Viagra, it is crucial to seek guidance from a medical professional. Particularly if you have any pre-existing health issues or are currently taking other medications. Inform your doctor about any past occurrences of heart disease, high or low blood pressure, liver or kidney complications. Also, alert them about any allergic reactions you may have had to sildenafil or similar medications.

Viagra should not be taken by individuals who are already using nitrates for chest pain or heart problems. The combination of sildenafil with nitrates can cause a severe drop in blood pressure. This can lead to dizziness, fainting, or even a heart attack. It is crucial to disclose all medications you are currently taking to your doctor to ensure there are no potential interactions.

Some contraindications for sildenafil include:

Nitrate medications. Sildenafil should not be taken by individuals who are using nitrate medications. These include: nitroglycerin, isosorbide mononitrate, or isosorbide dinitrate. Combining sildenafil with nitrates can cause a severe drop in blood pressure, leading to a potentially dangerous condition.
Cardiovascular conditions. Sildenafil may not be suitable for individuals with certain cardiovascular conditions. These include severe heart disease, unstable angina (chest pain), or recent heart attack or stroke. Generally, it is important to consult a healthcare professional to assess the risks and benefits of sildenafil in these cases.
Hypotension. Sildenafil can lower blood pressure. Individuals with low blood pressure (hypotension) should use sildenafil with caution. It is advisable to discuss this with a healthcare provider before taking the medication.
Severe liver or kidney disease. Sildenafil is metabolized in the liver and excreted through the kidneys. Individuals with severe liver or kidney disease may have difficulty metabolizing and eliminating the drug properly. The dosage may need to be adjusted or sildenafil may need to be avoided.
Retinal disorders. Sildenafil may have an effect on vision. Individuals with certain retinal disorders, such as retinitis pigmentosa, should use sildenafil with caution. We recommend seeking medical advice before taking the medication.
Allergy or hypersensitivity. If you have a known allergy or hypersensitivity to sildenafil or any of its ingredients, you should not take this medication.

Potential Side Effects

Like any medication, Viagra can have side effects, although not everyone experiences them.

Some possible adverse effects associated with sildenafil include:

Headache. This is one of the most common side effects. It is typically mild to moderate in intensity.
Flushing. Some people may experience redness or warmth in the face, neck, or chest after taking sildenafil. This is due to increased blood flow.
Indigestion. Sildenafil can cause gastrointestinal symptoms such as indigestion, acid reflux, or an upset stomach.
Nasal congestion. It is possible to experience a blocked or stuffy nose as a result of taking sildenafil.
Vision changes. Sildenafil can cause temporary changes in vision, such as a bluish tinge or increased sensitivity to light. Rarely, it may affect color vision.
Dizziness. Some individuals may experience dizziness or lightheadedness after taking sildenafil. It is important to avoid activities that require alertness until you know how your body responds to the medication.
Back pain and muscle aches. These side effects are less common but can occur in some individuals.

You must consult a doctor if you experience any persistent or severe side effects from sildenafil. Additionally, there are certain situations where you should use Sildenafil with caution. Such are in individuals with certain medical conditions or those taking specific medications. Be sure to disclose your full medical history and medications you are currently using to your doctor. This will ensure the safe and appropiate use of Sildenafil.

Why choose ZPHC Store?

When considering to buy Viagra online, it is crucial to choose a reliable and reputable source. ZPHC store is an established online pharmacy that offers generic Sildenafil at an affordable price. We focus on customer safety and ensure that the products we provide are of high quality and meet the international standards.

To place an order you will only need add your desired product to cart, enter shipping details and select your delivery and payment methods. Generally, it takes up to 21 days for international delivery and up to 5 days for US domestic.